PROSAC (Proteostasis and Cancer)
Publications Highlights

EMBO Reports
Published on may 5th, 2021
Sicari D, Centonze FG, Pineau R, Le Reste PJ, Negroni L, Chat S, Mohtar MA, Thomas D, Gillet R, Hupp T, Chevet E, Igbaria A. Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors. EMBO Rep. 2021 May 5;22(5):e51412.
Cancer Letters
Published on december 1st, 2020
Le Reste PJ, Pineau R, Voutetakis K, Samal J, Jégou G, Lhomond S, Gorman AM, Samali A, Patterson JB, Zeng Q, Pandit A, Aubry M, Soriano N, Etcheverry A, Chatziioannou A, Mosser J, Avril T, Chevet E. Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo. Cancer Lett. 2020 Dec 1;494:73-83.
EMBO Molecular Medecine
Published on june 2019
Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E. Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation. EMBO Mol Med. 2019 Jun;11(6):e10120. doi: 10.15252/emmm.201810120.
EMBO Molecular Medecine
Published on march 2018
Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E. Dual IRE1 RNase functions dictate glioblastoma development. EMBO Mol Med. 2018 Mar;10(3):e7929. doi: 10.15252/emmm.201707929.
BMC Cancer
Published on december 4th, 2018
Monnier A, Boniface R, Bouvet R, Etcheverry A, Aubry M, Avril T, Quillien V, Chevet E, Mosser J. The expression of EMX2 lead to cell cycle arrest in glioblastoma cell line. BMC Cancer. 2018 Dec 4;18(1):1213. doi: 10.1186/s12885-018-5094-y.