Here you will find current positions availaible in the OSS unit
Master 2 internship : Development of a preclinical model of Her2+ breast cancer brain metastasis.
Under the supervision of Drs Le Gallo (Inserm U1242) & Jarry (Oncotrial) the M2 intern will participate in the development of a preclinical mouse model of breast cancer brain metastasis.
Brain metastasis affects 7-11% of Her2+ breast cancer at diagnosis and is the most frequent metastasis site for this type of tumor.
The two teams have developed expertise in this type of murine model from previous collaborative work on other subtypes of breast tumors. The project will require the implementation of various techniques including stable cell line transfection, cell sorting, and immune phenotyping, bioluminescence imaging of live animals, histopathology, and transcriptome analysis depending on the project’s progress.
The candidate will primarily work in Oncotrial but some of the experiments will be performed in the Inserm lab.
For further inquiries on the project please contact Drs Ulrich Jarry and Matthieu Le Gallo: matthieu.legallo(at)univ-rennes1.fr
Master 2 internship : Regulation of Death Receptor signalling in cancer cells.
Death Receptor (DR), including CD95 and TRAIL-R1/2, are key regulators of tumour progression through their ability to drive cell death and non-cytotoxic cellular outcomes. Recent studies have highlighted ubiquitination events as crucial controllers of DR-signalling cellular outcomes. We have recently identified that UFL1, the E3-ligase for the ubiquitin-like modification UFM1, regulates TRAIL- and CD95L-induced cell death signalling in triple-negative breast cancer cells. Our preliminary results also indicate that UFL1 controls early events of DR signalling.
The aim of the internship is to further decipher the molecular mechanism underlying UFL1’s role in DR cell death signalling and to explore the impact of UFMylation on non-cytotoxic outcomes of DR signalling. The internship will involve biochemistry, cell biology and molecular biology techniques (cell culture, western blot, pull-down/immunoprecipitation, flow cytometry, BioID).
For further inquiries on the project please contact Dr Elodie Lafont: elodie.lafont(at)univ-rennes1.fr