You are here : Accueil > Research > Group 3 > People

People

Rémy Pedeux

Researcher Inserm

Short Bio:
During my PhD I investigated the response of melanocytes to UV irradiation under the supervision of Dr Jean-François Doré (INSERM 453, Lyon, France). As a postdoctoral fellow in Dr Curtis Harris Laboratory (Laboratory of Human Carcinogenesis, NCI/NIH, Bethesda, USA), I participated in the identification and characterization of a new family of tumor suppressor genes, the ING (INhibitor of Growth) genes.

In 2005, I returned to France in the laboratory of Pr Christian Brambilla (INSERM U823, Grenoble) and set up a project aiming at understanding by which mechanisms ING proteins and especially ING2 could play a role in tumor suppression.

In 2009 I joined the INSERM U917 in Rennes (Pr Karin Tarte), in partnership with EFS-Bretagne and was recruited as an INSERM investigator in 2010.

In 2015 I joined the newly created OSS laboratory. My project aims at elucidating the role played by ING genes in lung carcinogenesis. Apart from my main project, I am interested in the mechanisms of cellular senescence as well as the cellular and tumor response to radiotherapy.

Links:

Thierry Guillaudeux

Associate Professor University Rennes 1

Short Bio:
During my PhD I investigated the methylation status and the expression of MHC class 1 genes during development (INSERM Toulouse). As a postdoctoral fellow in Dr Geraghty laboratory at the Fred Hutchinson cancer center (Seattle) I sequenced the full MHC class 1 region in human.

In 1998 I obtained an Associate Professor position in the University of Rennes1. My main research interest is the TNF receptor family members and apoptosis induction in cancer and the regulation of apoptosis using combined therapies.

In January 2016 I joined the OSS Research unit where I study the genetic profile of Small cell carcinomas in primary and circulating tumor cells in human. I am also the director of UMS Biosit supervising the core facilities in life sciences in Rennes.

Links:

Hervé Lena

Physician MD, PH University Hospital Rennes 1

Short Bio:
I graduated as an MD in 1993 with a specialization in pulmonology and medical oncology. My fields of interest are clinical trial phases I to III in lung cancer, (chemotherapy, inmmunotherapy, targeted therapies, radiation therapies). I have been a PI of more than 40 studies since 2001. I am a member of EORTC, GFPC and IFCT.

Links:

Romain Corre

MD, PH University Hospital Rennes 1

Short Bio:
I was resident in pneumology between 1999 and 2003 and acquired my medical license in 2003 as specialist in pneumology at the Medical University of Caen, France. I completed in 2003/2004 a degree of specialist in thoracic oncology at the center for cancer research in Caen, France.

In 2004-2006, I worked as hospital Assistant – Senior University Registrar in the Hospital of Rennes. Since 2006, I’ve worked as hospital practitioner, department of Pneumology, in the general Hospital of Rennes. My main research interest is thoracic oncology and I’m more especially involved in industrial or academic clinical trials as investigator or sometimes coordinator.

In January 2016 I joined the OSS Research unit.

Links:

Benoit Desrues

MD, Professor University Hospital Rennes 1

Short Bio:
As a pulmonologist, head of the pulmonary medicine department of Rennes university hospital, I am particularly involved in cystic fibrosis, non-invasive ventilation in chronic respiratory failure and respiratory sleep disorders.

As a research fellow at the Mayo Clinic in the Thoracic Diseases Research Unit (MS Rohrbach) I worked on release of arachidonic acid from alveolar macrophages. Afterwards, I investigated, during my PhD, the biodistribution and treatment options of a radiolabeled monoclonal antibody in human lung tumor-bearing mouse model (Centre Régional de Lutte Contre le Cancer, Rennes).

Joining the OSS research laboratory offers me the opportunity to continue research on xenografts models.

Links:

Florence Jouan

Technician University Rennes 1

Short Bio:
As a technician for research and education, I worked in the Rennes IGDR in the research team "Kidney cancer: molecular basis of tumorigenesis” for the last 10 years.

In October 2015, I joined the Rennes OSS unit to participate in the study of lung cancer and take advantage of my skills in histology techniques, cell culture, biochemistry, experimentation and surgery on small animals.

Links:

Charles Ricordel

MD, PhD Student

Short Bio:
I am a pulmonologist involved in the field of thoracic oncology. After a Master degree obtained in 2014, I graduated from my clinical fellowship in november 2016. I obtained a grant (FHU CAmin 2016) to conduct a Ph.D during 3 years, in the OSS lab at the CLCC Eugène Marquis (University of Rennes 1), in order to explore the role of ING tumor suppressor proteins in lung malignancies.

Other Research Interests: lung cancer, tumor heterogeneity, clonal evolution upon targeted therapies, circulating tumor cells.

Links:

Audrey Mouche

PhD Student

Short Bio:
I am a PhD Student working under the supervision of Dr Remy Pedeux in OSS research unit. Initially, I graduated with a Bachelor degree in Molecular and Cellular Biology from Rennes 1 University and a Master degree in Immunology from Strasbourg University.

In OSS research unit, I am working on the involvement of ING tumor suppressor genes in the DNA damage response.

Links:

Kathy Yaacoub

PhD Student

Short Bio:
I am a Lebanese student. I graduated from the doctoral school of sciences and technologies-Lebanese University with a Master degree in Immunology/Molecular Biology.

I started my Ph.D in 2014 at the University Rennes 1. My thesis is entitled: “c-FLIP as an anticancer target: Enhancement of cell apoptosis by compounds identified in silico”. The aim of our project is to inhibit the anti apoptotic function of c-FLIP protein by newly identified molecules, thereby restoring apoptosis in cancer cells. This work may help to design new strategies in cancer treatment field.

Links:

Charlotte Andrieu

PhD Student

Short Bio:
I’m a PhD student working on the characterisation of small-cell lung cancer. BSc in Biology and Animal Physiology at the Université de Caen Basse-Normandie (France, 61) and Aberystwyth University (UK, Wales). MSc in Genetics, Physiology and Bioinformatics, specialising in Data Analysis and Modelling at the Université Blaise-Pascal (Clermont-Ferrand II) in France (63).

Due to my love of travel and new experiences, I have worked at both IBERS (Institute of Biological and Rural Sciences) in Wales on the detection of candidate genes for leucism in red kites (Milvus milvus), and at deCODE genetics at Reykjavik (Iceland) on region-based association testing on the Icelandic population data.

Links:

Lab Alumni

Group 3
Pedeux