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Patrick Legembre

Research Director Inserm

Short Bio:
2002-2005: As a Post-Doctoral Research Associate, I joined Marcus Peter’s laboratory at the University of Chicago, where we established that engagement of CD95 in malignant cells resistant to the CD95-mediated apoptotic signal triggers non-apoptotic signalling pathways such as NFκB and MAPK (EMBO reports, 2004; EMBO J., 2004). This study drew attention to the potential pro-oncogenic role of CD95.

2005-2009: as a Principal Investigator in the laboratory of Prof. Jean-François Moreau (University of Bordeaux-2, France), we discovered that the redistribution of CD95 into lipid rafts promotes the initial steps of apoptotic signaling (Cell Death and Diff., 2002, Mol. Cell Biol., 2005 and J Immunol., 2006).

Since 2010, as leader of the “Death Receptors & Tumor Escape” (DR@TE) Team (University of Rennes-1, France), we demonstrated that in contrast to membrane-bound CD95L, metalloprotease-cleaved CD95L (cl-CD95L) participates in the progression of i) lupus disease by promoting accumulation of activated T lymphocytes in damaged organs (PLoS Biology, 2011) and ii) triple negative breast cancers by enhancing cell migration of tumor cells (Cancer Res, 2013). In parallel, DR@TE Team dissected the rapid and transient anti-apoptotic role of Ca2+ in the initial steps of CD95 signalling (PNAS, 2011). Overall, these findings revisit the role of CD95 as a death receptor and bring to light its participation in promoting chronic inflammatory disorders.

Since January 2015, we created INSERM OSS lab at the CLCC Eugène Marquis, University of Rennes 1, Rennes.


Jean Levêque

PU-PH, HDR, CHU Rennes/CLCC Eugène Marquis

Short Bio:
Head of the gynecological service of Rennes CHU – Surgeon of the oncological surgical unit of the Rennes CLCC – Faculty member of the "UFR Médecine" of Rennes 1 University.

MD: 1989
Ph-D: 1999

Research Themes: breast cancer, pelvic cancer


Laure Debure

Associate Professor, University of Rennes 1

Short Bio:
1994-1996: Lecturer and Research Assistant in University of Rennes-1.

1996: Associate Professor of animal physiology of University of Rennes 1, CNRS UMR 6026.

1999-2008: I worked in the team of Pr. Denis Michel in UMR 6026 on clusterin, a secreted chaperone that accumulates during cellular stress. We demonstrated that its intracellular localization could trigger apoptosis in relation with its strong aggregative property (Debure et al., J. Cell Science, 2003).

At the end of 2008, I joined EA SERAIC and since 2010, I study the role of cleaved-CD95L in breast cancer cells.

Since 2012: Elected member of the board of directors of University of Rennes-1. Member of the finance committee and of the disciplinary


Astrid Lièvre

PU-PH, HDR, CHU Rennes/Université Rennes 1

Short Bio:
Medical training and qualification in hepato-gastroenterology and digestive oncology.
PhD – Pharmacology, cellular and molecular biology - translational research in digestive oncology.
Secretary of the FFCD (Fédération Francophone de Cancérologie Digestive) Scientific Committee.

1998- 2002 : residency, training in Hepato-Gastroenterology. Nantes University Hospital, France

2002-2003: master 2 « Biology and Pathology of Epitheliums ». INSERM U490 and University Paris VII, Paris, France. « Caracterization of mitochondrial DNA mutations in colorectal cancer and correlation with histopathologic phenotype and prognosis.

2003-2004 : MD in the Radiotherapy department and in the Digestive Oncology unit of the Institut Gustave Roussy, Villejuif, France.

2004- 2008 : PhD – Pharmacology, cellular and molecular biology. INSERM U775 and Paris Descartes University « Prognostic and predictive biomarkers of response to colorectal cancer treatments » INSERM U775, Paris and Paris Descartes University.

2005-2007 : MD and University assistant, Ambroise Paré University Hospital - Faculty of Medicine Paris-Ile de France Ouest, Versailles University, Paris.

2007-2009 : MD and University assistant, University Georges Pompidou European Hospital -Faculty of Medicine, Paris Descartes University, Paris.

2009-2012 : MD and University assistant, Ambroise Paré University Hospital - Faculty of Medicine Paris-Ile de France Ouest, Versailles University, Paris.

2012-2015 : MD and Associate Professor, Institut Curie-Faculty of Medicine Paris-Ile de France Ouest, Versailles University.

Since 2015: Professor of Medicine, Rennes University Hospital - Rennes 1 University and researcher in INSERM OSS lab INSERM U1242,OSS lab.

Research Themes: colorectal and anal cancer, digestive cancer, prognostic biomarker, predictive biomarker of respoonse to treatments


Franck Jegoux

Professor (full professorship) University Hospital – Rennes, France
Specializations: Head and Neck Cancer Surgery; Reconstructive surgery; Oncology; Otorhinolaryngology

Short Bio:

Medical course and certification:

2014-2017 Juridical expert on behalf the Appeal Court of Rennes

2013: Qualification in Legal redress of physical injury

2012: Certification in Oncology

2011: Certification Full Professorship

2004-2011 MD, Head and Neck Surgery, Rennes

2004: Qualification in Head and Neck Plastic and Reconstructive Surgery, Lyon, France

2003: Qualification in Head and Neck Oncology, Institut Gustave Roussy, Paris XI, France

2003: Certification in Head and neck Surgery, University of Nantes, France

2002: Certification in Otorhinolaryngology, University of Nantes, France

2002-2004: Assistant Professor, Head and Neck Surgery, Nantes University Hospital

2002: MD degree certification: “Ethmoid adenocarcinoma”

1996-2002: Resident: Department of Otorhinolaryngology, Head and Neck Surgery, Nantes University Hospital

Research course:

2016- INSERM U1242 COSS membership

2008-2016: INSERM U791 LIOAD membership

2010 Research Habilitation Degree

2009 Cancer Center from the Cliniques Universitaires Saint-Luc King Albert II Institute

2004-2008: PhD Biology-Chemistry /Field : Clinical research, technologic innovation. Nantes, Novembre 2008. « Mandibular reconstruction by phosphocalcic ceramics »

2000: Master's of science, University of Paris V, France

1998: Bachelor of science, University of Nantes, France

Research Themes: Head and neck cancer; Immune environment; Node involvement; Predictive biomarkers of response to treatments


Vincent Lavoué

PU-PH, HDR, CHU/CLCC Eugène Marquis

Short Bio:
2001-2006: Gynecologist Internship, Teaching Rennes Hospital, France

2006-2009: Clinical Fellow Ship, Teaching Rennes Hospital, France

2009-2012: PhD Student, Rennes University, France (I studied how immunosuppressive microenvironment of ovarian cancer alleviate cytotoxic functions of Vgamma9Vdelta2 T cells)

2013: Post-Doctoral Research Associate, X chromosome and Cancer, McGill University, Montreal, Canada (I studied how FoxP3 gene expression in ovarian cancer cells correlates with apoptotic response to chemotherapeutic agents)

Since 2014: oncologist surgeon in gynecology surgery department (Rennes Teaching Hospital) and breast surgery department (CLCC Eugène Marquis) and researcher in INSERM OSS lab

Research Themes: ovarian cancer


Brigitte Collet

Engineer, CLCC

Project: //

Short Bio:
CLCC Engineer in Cell biology. I worked in Nuclear Medicine Department (Topic: Scintigraphy detection of inflammatory and tumor foci), Clinical Department (Topic: p53 role in squamous cell carcinoma of the oesophagus), Immunotherapy Unit (Topic: tumor-associated antigens expression in melanoma and glioblastoma patients) and Proteomic Unit (Topic: proteomic analysis in glioblastoma cells).

Since 2015, I joined the team to study CD95-mediated signaling pathway.

Ph.D: 1982

Research Themes: //


Matthieu Le Gallo


Project: //

Short Bio:
Since October 2015: I am a research engineer in the lab of Dr. Patrick Legembre. I focus my research on the characterisation of the transcriptome of triple negative breast cancer stem cells.

2010-2015: Postdoctoral fellow, Cancer Genetics Branch, Reproductive Cancer Genetics section, NIH/NHGRI, Bethesda MD, USA. Dr. Daphne W. Bell (section head). I worked on the identification of genomic alterations driving the clinically aggressive serous, clear cell and carcinosarcomas tumours of the endometrium. We used whole exome sequencing to systematically catalogue genomic alterations in these tumour types. We were the first team to report driver genomic alterations in chromatin remodelling genes in these tumours. I established the bioinformatics pipeline to analyse next generation data in the lab.

2008‐2010: Junior postdoctoral researcher, Dog genetics team, Institute of Genetics and Development of Rennes CNRS & University of Rennes 1, France Dr. Catherine André (Research Director). I developed a research project aiming at characterising the gene expression profiles of tumours from Bernese mountain dogs affected with histiocytic sarcoma, a spontaneous tumour sharing a similar physiopathology with a rare paediatric non-Langerhans histiocytic disorder of unknown aetiology.

2004‐2008: Ph.D. Thesis in Immunotherapy, under the supervision of Pr. Véronique Catros EA 3891 “Biothérapies Innovantes”, University of Rennes 1, France.

Research Themes: //


Emna Mahfoudhi


Project: //

Short Bio:
2011-2015: PhD student in U1170 « Hématopoïèse normale et pathologique » laboratory at Gustave Roussy Cancer Campus, Villejuif (Université Paris Sud). I worked in the role of TET2 and P53, two tumor suppressors, in a hematopoietic context. We have shown that 5-hydroxymethylcytosines induced by TET2 over expression induces genomic instability and mutagenesis, particularly in the absence of TDG, a key protein in the BER pathway. We have also shown that activation of p53 by MDM2 antagonists has a deleterious and not reversible effect on all hematopoietic progenitors.

Since July 2016, I joined the OSS lab (group 1) to work on the role of CD95 cleavage in non apoptotic pathways.

Research Themes: //


Jean-Philippe Guégan


Project: //

Short Bio:
2009-2012: PhD student in EA SERAIC (University of Rennes 1, France) where I studied the involvement of the MAPK pathway in the development and progression of liver cancer.

2013-2016: Post-doctoral fellow at the Institute of Research in Immunology and Cancer (University of Montreal, Canada) where I studied the regulation of RRas GTPases by the MAPK pathway.

2016-2017: Study director, in vivo oncology, in a CRO (Porsolt, laval, France).

Since June 2017, I joined the OSS lab to work on the pro-oncogenic role of the CD95/CD95L pathway.

Research Themes: //


Elodie Lafont

Project: //

Short Bio:
2008-2011: PhD student in Pr Thierry Levade’s team (Centre de Recherche en Cancérologie de Toulouse, France), under the supervision of Pr Bruno Ségui and Hervé Benoist. We focused on unravelling the role of initiator caspases and sphingolipids in TRAILR1/2 and CD95-mediated apoptosis.

2012-2018: Research associate in Pr Henning Walczak’s group (Cancer Institute, University College London, United Kingdom). We demonstrated the crucial role of a particular post-translational modification (PTM) called linear ubiquitination in driving TRAIL-induced cytokine production whilst limiting apoptosis and necroptosis (Lafont et al., EMBO Journal, 2017). We also discovered that two kinases, TBK1 and IKKε, constitute a crucial cell death checkpoint, restraining TNF-induced RIPK1 activation, and thereby cell death in vitro and in vivo (Lafont et al, Nature Cell Biology, 2018).

In May 2018, I joined Dr Patrick Legembre’s team to define the molecular bases of CD95’s pro-oncogenic and pro-inflammatory roles.

Research Themes: //


Lab Alumni

  • Posts-Docs

  • A. Fouqué
  • D. Sanséau
  • V. Edmond
  • M. Malleter
  • S. Tauzin
  • B. Chaigne-Delalande
  • Period

  • -
  • -
  • 2011-2013
  • 2011-2013
  • 2010-2012
  • 2007-2009
  • Current Position

  • Engineer, Microbs, Rennes
  • Post-doc, Curie, France
  • Engineer, IGR, Paris
  • Engineer, Biosit, Rennes
  • Anna Huttenlocher Lab, University of Wisconsin-Madison, USA
  • Associate professor, Michael Lenardo Lab, Washington, USA

PhD Students

  • Amanda Poissonnier
  • N. Khadra
  • H. Rampanarivo
  • M. Pizon
  • G. Guidicelli
  • PhD 2017
  • PhD 2012
  • PhD 2012
  • PhD 2010
  • PhD 2009
  • Post-doc, Portland Coussens Lab, USA
  • Technical sales representative, Ozyme
  • -
  • Intern in CHU Bordeaux
  • Hospital practitioner, CHU Bordeaux

Group 1