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Cancer discovery: issue June 2015

Published on july 6th, 2015 by Eric Chevet

Chevet E, Hetz C, Samali A.
Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis.
Cancer Discov. 2015 Jun;5(6):586-597. Epub 2015 May 14. Review.

SIGNIFICANCE: ER stress signaling is dysregulated in many forms of cancer and contributes to tumor growth as a survival factor, in addition to modulating other disease-associated processes, including cell migration, cell transformation, and angiogenesis. Evidence for targeting the ER stress signaling pathway as an anticancer strategy is compelling, and novel agents that selectively inhibit the UPR have demonstrated preliminary evidence of preclinical efficacy with an acceptable safety profile. Cancer Discov; 5(6); 586-97. ©2015 AACR.