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Molecules to treat lupus and TNBC patients

Published on November 22nd, 2018 by Patrick Legembre

ABSTRACT: CD95L is a transmembrane ligand (m-CD95L) that is cleaved by metalloproteases to release a soluble ligand (s-CD95L). Unlike m-CD95L, interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD to...

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Molecules to treat lupus and TNBC patients

Published on July 26th, 2016 by Patrick Legembre

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease associated with a degradation of different organs (kidneys, skin, joints, brain, lung, heart). In collaboration with teams from Bordeaux and...

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Scientific report

CD95 promotes metastasis by activating NHE1

Published on June 15th, 2016 by Patrick Legembre

ABSTRACT: Transmembrane CD95L (Fas ligand) can be cleaved to release a promigratory soluble ligand, cl-CD95L, which can contribute to cancer cell dissemination in patients affected by triple negative breast cancer (TNBC)...

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Thesis prize Fondation Rennes-1

Thesis prize fondation Renne-1

Published on March 30th, 2016 by Patrick Legembre

ABSTRACT: Amélie Fouqué (Legembre Team) won the first prize Fondation Rennes-1 (Biology) for her discovery of a novel mTOR inhibitor that the Unit in collaboration with SATT Ouest Valo is accompanying to clinical Trial...

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DHM25, a new Covalent mTOR Inhibitor

DHM25, a new Covalent mTOR Inhibitor

Published on August 11th, 2015 by Patrick Legembre

ABSTRACT: Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers. From a chromene backbone reported to inhibit class I PI3K catalytic subunits...

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nature cell biology issue 2015

Nat Cell Biol. issue July 2015

Published on july 9th, 2015 by Eric Chevet

ABSTRACT: Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed in many physiological and pathological conditions. To cope with endoplasmic reticulum...

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cancer discovery issue june 2015

Cancer discovery: issue June 2015

Published on july 6th, 2015 by Eric Chevet

SIGNIFICANCE: ER stress signaling is dysregulated in many forms of cancer and contributes to tumor growth as a survival factor, in addition to modulating other disease-associated processes...

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oncogene issue 2015

Oncogene 2015

Published on june 24th, 2015 by Patrick Legembre

DR@TE Team and collaborators published a study demonstrating that Ceramide synthase 6 (CerS6) is down-regulated during epithelial to mesenchymal transition (EMT). Reduction of CerS6...

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