• Animal cell cut-away
  • Breast Cancer - Female Anatomy - tumor highlight
  • cerebral tumor
  • close up of Molecular structure model


The INSERM U1242 COSS laboratory is a translational research structure bringing together biologists and clinicians to better understand oncogenesis in brain and gynecological cancers. By associating biologists working on cancer stress signaling pathways and cancer clinicians, the laboratory aims at deciphering how tumor cells cope with stresses to resist to death. Moreover, COSS researchers collaborate with chemists for the design and synthesis of novel pharmacological molecules that target the relevant stress signaling pathways.


nerve cells, Neurologic Diseases, tumors



cancer cells


Proteostasis and Cancer (PROSAC)

Maintaining protein homeostasis also named proteostasis is important in the normal ‘housekeeping’ of the body and of the cells and plays a critical role in cancer. The PROSAC team focuses on Endoplasmic Reticulum proteostasis control in cancer and on the role of the SUMO/Ubiquitin interplay in the DNA damage response.

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