• Animal cell cut-away
  • Breast Cancer - Female Anatomy - tumor highlight
  • cerebral tumor
  • close up of Molecular structure model

ABOUT

The INSERM U1242 COSS laboratory is a translational research structure bringing together biologists and clinicians to better understand oncogenesis in brain and gynecological cancers. By associating biologists working on cancer stress signaling pathways and cancer clinicians, the laboratory aims at deciphering how tumor cells cope with stresses to resist to death. Moreover, COSS researchers collaborate with chemists for the design and synthesis of novel pharmacological molecules that target the relevant stress signaling pathways.

TEAMS

nerve cells, Neurologic Diseases, tumors

TEAM 1

Death Receptors & Tumor Escape (DR@TE)

The Team aims at 1) showing how CD95 switches from implementing cell death to non-apoptotic signaling pathways, 2) characterizing the cells whose function is deregulated by the naturally processed ligand in breast cancers and 3) generating with chemists original inhibitors of the CD95-mediated non-apoptotic signaling pathways.

cancer cells

TEAM 2

Proteostasis and Cancer (PROSAC)

Maintaining protein homeostasis also named proteostasis is important in the normal ‘housekeeping’ of the body and of the cells and plays a critical role in cancer. The PROSAC team focuses on Endoplasmic Reticulum proteostasis control in cancer and on the role of the SUMO/Ubiquitin interplay in the DNA damage response.

Latest news

Disrupting the CD95-PLCγ1...

Nature Chemical biology logo

ABSTRACT: ABSTRACT: CD95L is a transmembrane ligand (m-CD95L) that is cleaved by metalloproteases to release a soluble ligand (s-CD95L). Unlike m-CD95L, interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD to...

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Molecules to treat lupus and TNBC...

immunity

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease associated with a degradation of different organs (kidneys, skin, joints, brain, lung, heart). In collaboration with teams from Bordeaux...

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CD95 promotes metastasis by...

CD95 promotes metastasis by activating NHE1

ABSTRACT: Transmembrane CD95L (Fas ligand) can be cleaved to release a promigratory soluble ligand, cl-CD95L, which can contribute to cancer cell dissemination in patients affected by triple negative breast cancer (TNBC)...

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Elife: Extracellular role of AGR2

Elife Extracellular role of AGR2

Fessart D, Domblides C, Avril T, Eriksson LA, Begueret H, Pineau R, Malrieux C, Dugot-Senant N, Lucchesi C, Chevet E, Delom F. Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties.

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